+Polymeric nanoparticles
for aerosol gene delivery
Tether is an mRNA therapeutics company developing inhalable treatments for life-threatening respiratory diseases using our proprietary polymer formulations.
WHAT WE DO
next
generation
delivery solution
Optimized for lung delivery, our polymers are a next generation delivery solution based on novel chemistry developed at Georgia Tech and Emory University.
+Addressing the bottlenecks of other delivery systems
Biodegradable polymers offer vast potential as next-generation gene delivery vehicles. The tunable chemical structure of polymers enables the design of particles that can be engineered to reduce cytotoxicity, optimize cargo capacity, and increase affinity for specific tissue or cell types.
+A differentiated approach to lung delivery
Prior approaches to respiratory gene therapy have utilized LNPs, which lack the potency, flexibility and tolerability required for effective aerosol delivery to the lungs. Tether’s platform exploits the tunable chemical structure of biodegradable polymers to address these bottlenecks.
Potency
Protein expression orders of magnitude higher than previously studied LNPs
Tolerability
No signs of inflammation or toxicity exhibited in rodent and NHPs deliveries
Translatable Delivery
Demonstrated expression across the airways and lungs of six different species
Payload-agnostic Chemistry
Capable of carrying nucleic acid payloads of various sizes, including mixed payloads
