+First generation gene therapies have created significant value via delivery to only a few tissue and cell types.
The tunable chemical structure of polymers enables design of tailor-made particles that can be engineered to reduce cytotoxicity, optimize cargo capacity, and increase affinity for specific tissue or cell types. The potency and flexibility of these nanoparticles makes them an ideal fit for addressing the challenges of aerosol delivery.
Optimized for lung delivery, our proprietary class of polymers are a next-generation delivery solution based on novel chemistry developed at Georgia Tech and Emory University. Tether’s proprietary polymer formulations address the bottlenecks facing first-generation approaches, and outperform leading LNPs in delivery to the lungs.
Potency
Protein expression orders of magnitude higher than previously studied LNPs
Tolerability
No signs of inflammation or toxicity exhibited in rodent and NHPs deliveries
Translatable Delivery
Demonstrated expression across the airways and lungs of six different species
Payload-agnostic Chemistry
Capable of carrying nucleic acid payloads of various sizes, including mixed payloads